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Coronavirus Patent By Pirbright Institute, Funded By Gates Foundation, (Climate Change Scam #15?)

Coronavirus Patent By Pirbright Institute, Funded By Gates Foundation, (Climate Change Scam #15?)

1. Important Links

CLICK HERE, for patent information on Coronavirus (filed in 2015). http://archive.is/n6Glh CLICK HERE, for Pirbright Institute’s other patents. http://archive.is/ta93g CLICK HERE, for the Pirbright Institute, UK. http://archive.is/GqAiL CLICK HERE, for Coronavirus and Pirbright Institute. http://archive.is/btkMI CLICK HERE, for Bill Gates funding Pirbright Institute. http://archive.is/WbdNH CLICK HERE, for Pirbright/Coronoavirus FAQ section. http://archive.is/knC79 CLICK HERE, for disease simulation, predicting 65M dead. http://archive.is/KJGpl CLICK HERE, for article of Bill Gates telling of weaponized diseases (2017). http://archive.is/m2wGl CLICK HERE, for Chinese researcher removed from infectious diseases lab. http://archive.is/MeAfB CLICK HERE, for a Winnipeg researcher smuggling Ebola into USA. http://archive.is/tdZTK

2. Check Out Civilian Intelligence Network

Another Canadian researcher worth a close look on this subject. https://civilianintelligencenetwork.ca/2020/01/25/the-canary-is-dead-wuhan-coronavirus-launches-global-depopulation-plan/ https://civilianintelligencenetwork.ca/2020/01/27/bill-gates-the-coronavirus-conspiracy/ https://civilianintelligencenetwork.ca/2020/01/26/un-plans-to-blackmail-countries-for-coronavirus-vaccine/ There is tons of information on these 3 articles. Rather than rehashing or recreating what they have, here are the links to look for yourself.

3. Coronavirus Patent Application in 2015 (Pirbright)

Patent History Patent number: 10130701 Type: Grant Filed: Jul 23, 2015 Date of Patent: Nov 20, 2018 Patent Publication Number: 20170216427 Assignee: THE PIRBRIGHT INSTITUTE (Woking, Pirbright) Inventors: Erica Bickerton (Woking), Sarah Keep (Woking), Paul Britton (Woking) Primary Examiner: Bao Q Li Application Number: 15/328,179 Classifications Current U.S. Class: Coronaviridae (e.g., Neonatal Calf Diarrhea Virus, Feline Infectious Peritonitis Virus, Canine Coronavirus, Etc.) (424/221.1) International Classification: A61K 39/215 (20060101); C12N 7/00 (20060101); C12N 9/12 (20060101); A61K 39/00 (20060101); Coronavirus Jul 23, 2015 – THE PIRBRIGHT INSTITUTE The present invention provides a live, attenuated coronavirus comprising a variant replicase gene encoding polyproteins comprising a mutation in one or more of non-structural protein(s) (nsp)-10, nsp-14, nsp-15 or nsp-16. The coronavirus may be used as a vaccine for treating and/or preventing a disease, such as infectious bronchitis, in a subject. Description FIELD OF THE INVENTION The present invention relates to an attenuated coronavirus comprising a variant replicase gene, which causes the virus to have reduced pathogenicity. The present invention also relates to the use of such a coronavirus in a vaccine to prevent and/or treat a disease. More information is available here, but the point is this: the coronavirus was (allegedly) modified to help cure other diseases, such as bronchitis.

4. Pirbright Institute’s Other Patents

Attenuated African swine fever virus vaccine Patent number: 10507237 Abstract: The present invention provides an attenuated African Swine Fever (ASF) virus which lacks a functional version of the following genes: multigene-family 360 genes 9L, 10L, 11L, 12L, 13L and 14L; and multigene-family 505 genes 1R, 2R, 3R and 4R. The invention further provides an attenuated African Swine Fever (ASF) virus which lacks a functional version of the DP148R gene. The present invention also provides a vaccine comprising such an attenuated virus and its use to prevent ASF. Further, the invention relates to intranasal administration of an attenuated ASF virus. Type: Grant Filed: June 19, 2015 Date of Patent: December 17, 2019 Assignee: The Pirbright Institute Inventors: Charles Abrams, Ana-Luisa Reis, Chris Netherton, Linda Dixon, Dave Chapman, Pedro Sanchez-Cordon Stabilised FMDV capsids Patent number: 10294277 Abstract: The present invention relates to the stabilization of foot-and-mouth disease virus (FMDV) capsids, by specific substitution of amino acids in a specific region of FMDV VP2. The invention provides stabilized FMDV capsids and vaccines against FMD. Type: Grant Filed: March 25, 2014 Date of Patent: May 21, 2019 Assignee: The Pirbright Institute Inventors: Abhay Kotecha, David Stuart, Elizabeth Fry, Robert Esnouf Stabilised FMDV Capsids Publication number: 20190135874 Abstract: The present invention relates to the stabilisation of foot-and-mouth disease virus (FMDV) capsids, by specific substitution of amino acids in a specific region of FMDV VP2. The invention provides stabilised FMDV capsids and vaccines against FMD. Type: Application Filed: January 17, 2019 Publication date: May 9, 2019 Applicant: Pirbright Institute Inventors: Abhay Kotecha, David Stuart, Elizabeth Fry, Robert Esnouf Chicken cells for improved virus production Patent number: 10202578 Abstract: The present Invention provides as avian cell in which the expression or activity of one or more of the following genes, or a homologue thereof: Chicken IFITM 1 (SEQ ID No. 1); Chicken IFITM2 (SEQ ID No. 2) and Chicken IFITM3 (SEQ ID No. 3) is reduced. The invention also provides methods for passaging viruses in avian cells, embryos and/or avian cell lines which have reduced expression of one or more IFITM genes and methods which involve investigating the sequence of one or more of the following genes, or a homologue thereof: Chicken IFITM1 (SEQ ID No. 1); Chicken IFITM2 (SEQ ID No. 2) and Chicken IFITM3 (SEQ ID No. 3). Type: Grant Filed: June 3, 2014 Date of Patent: February 12, 2019 Assignee: THE PIRBRIGHT INSTITUTE Inventors: Mark Fife, Mark Gibson That is just a few patents that The Pirbright Institute has. Now it seems harmless enough. But what happens if or when one of their creations becomes weaponized and turned against the public?

5. Gates Foundation Finances Pirbright Inst.

📷 Researchers from The Pirbright Institute have been awarded US $5.5 million by the Bill & Melinda Gates Foundation to establish a Livestock Antibody Hub aimed at improving animal and human health globally. The ambitious programme of work will see extensive collaboration between multiple UK research organisations in order to utilise research outcomes in livestock disease and immunology to support human health as part of the ‘One Health’ agenda. Six leading scientists from Pirbright will be involved in the project, including Professor John Hammond, Professor Venugopal Nair, Dr Simon Graham, Dr Elma Tchilian, Professor Munir Iqbal and Dr Erica Bickerton. Their combined expert knowledge will drive the study of cattle, pig and poultry antibody responses at high resolution to expand our understanding of protective immunity in species that can also be used as models for a range of human infectious diseases. The aim is to use Pirbright’s expertise in livestock viral diseases, cutting-edge technology and unique high-containment facilities to bring antibody discovery, manipulation and testing up to the benchmark already seen in the immunological field for rodents and humans. “New tools have given us the opportunity to utilise these detailed antibody responses to make the next generation of vaccines and therapies” said research lead Professor Hammond. This highly collaborative work will address the needs of the livestock research community whilst bridging the requirements of the vaccine industry. A number of work programmes will focus on studying B cells and antibodies at multiple scales including gene expression, single cell function and the entire antibody response. Findings from this research will be used to drive vaccine selection and design and test antibody therapies, “which will improve animal health and ultimately human health, as well as ensuring the security of our food supply”, finished Professor Hammond. Pirbright will ultimately act as a ‘Hub’ able to provide specific methods, access to animal models and the associated expertise to drive antibody research within the ‘One Health’ agenda. “This is the single biggest investment in the immunology of livestock in the UK from an international funder, and the British Society for Immunology will do all we can to support this collaborative initiative and help maximise its impact for the benefit of human and animal health”, commented Dr Doug Brown, Chief Executive of the British Society for Immunology A major contributor to Pirbright Institute is the Gates Foundation, headed by Bill and Melinda Gates. Yes, those Gates. But why is that an issue? What’s wrong with a wealthy couple contributing to help prevent infectious diseases? Let’s put it this way: Bill Gates has some views that are (mildly) controversial. He has gone on record with comments that suggest be supports human depopulation — reducing the number of people on Earth. Could this be a way to accomplish that goal?
submitted by OwnPlant to conspiracy

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FAQ: Structural Rearrangements, Part 1 – Types of Mutations

This post is for the Wiki, so if you have any perspective on Structural Rearrangements, please contribute. We ask that you stick to answers based on facts and your own experiences, and keep in mind that your contribution will likely help people who know nothing else about you (so it might be read with a lack of context).
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When you’re dealing with structural rearrangements (SR or rearrangements for simplification), it is important to understand the type of mutation you have, and what it means for your odds of conceiving without assistance or via IVF. Different rearrangements have different outcomes and limitations. The intent of this post is to:
· Inform the basic reader on the different types of mutations
· Understand how rearrangements are found
· Additional support offerings
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Additional perspective from our members with Structural Rearrangements will be helpful for the following questions:
· How was your SR found?
· How has this affected your perspective around infertility?
· What ART (assisted reproductive technologies) have you pursued and how has your SR influenced the outcome?
· If you found success, what did this mean for monitoring during your pregnancy?
note for our SR commenters: stay neutral and to the point. This is highly relevant for SRs, as pregnancy without assistance is possible, but carries significant risks. We appreciate anything you can share neutrally that is a knowledge add.
note for our community – I expect us all to act like adults. Be compassionate and understand that their infertility has radically affected their life and their pregnancy. It is not against the rules to neutrally discuss, and it is highly relevant here
· Did I miss something important? Add it in the comments please!
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Disclaimer: I am not a medical professional; this is just information I have learned due to our diagnosis. If there are errors or you have a recommendation to clarify something confusing, please reach out to me so I can correct this post. I have the most knowledge around balanced reciprocal translocations since this is our diagnosis, FYI.
PART TWO delayed until late Nov - on meiosis and the impact of structural rearrangements on fertility
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Rearrangements change the chromosomal structure and can alter the function of one or more genes and can change the pattern of gene transmission. Of the 23 pairs of chromosomes (46 in total for humans), there are 4 types of rearrangements that can affect our 46 chromosomes, with each type having distinct cytological and genetic consequences.
Sidenote: These mutations can be spontaneously created (de novo) or inherited. Most of the rearrangement mutations we discuss in this post are most likely inherited from family members. We are not discussing any possible implications of one's health with a rearrangement (mostly minimal), instead we are discussing the outcomes of infertility with respect to the particular rearrangement.
1) Deletion
A rearrangement that removes a segment of DNA, and sometimes known as partial monosomies. Deletions can be located within a chromosome (interstitial) or can remove the end of a chromosome (terminal). Deletions can be small (intragenic), affecting only one gene, or can span multiple genes (multigenic). Deletions that are too small to be detected under a microscope are called microdeletions. A person with a deletion has only one copy of a particular chromosome segment instead of the usual two copies. A deletion does not always lead to infertility or repeat pregnancy loss (RPL), but it can sometimes be the cause of non-obstructive azoospermia. The effects of the deletions depend on their size, with most multigenic deletions having severe consequences up to and including lethality. Deletions are further complicated by recessive traits, gene expression, deletion loops, pseudodominance, and heterozygous v homozygous genes.
2) Duplications
A rearrangement that results in an increase in copy number of a particular chromosomal region, sometimes known as partial trisomies. A person with a duplication has three copies of a particular chromosome segment instead of the usual two. Like deletions, these can happen anywhere along the chromosome. There are two types of duplications – tandem where the duplicated regions lie right next to one another, or non-tandem where the repeated regions lie far apart on the same or different chromosomes. Again, this doesn’t always lead to infertility, but it depends on the duplication.
3) Inversions
A rearrangement in which a chromosomal segment is rotated 180 degrees. Inversions are defined by the involvement of the centromere. Pericentric inversion includes the centromere (peri means around/about), and Paracentric inversion does not include the centromere (para means beside/beyond). In other words, an inversion is where a chromosomal region is flipped around so that it points in the opposite direction. Most inversions will result in reduced infertility, as the inversion will lead to a larger amount of unbalanced gametes (heterozygous v homozygous is relevant here). This can also have deleterious effects on a person, with hemophilia also being caused by an x-linked inversion in the factor VIII gene (although most inversions do not have any effect on the person).
4) Translocations
A rearrangement in which part of one chromosome becomes attached to another chromosome. A reciprocal translocation involves two chromosomes swapping segments; a non-reciprocal translocation means that a chunk of one chromosome moves to another. Translocations can be balanced (in an even exchange of material with no genetic information extra or missing) or unbalanced (where the exchange of chromosome material is unequal resulting in extra or missing genes). For the most common type of translocation, balanced reciprocal translocation, this occurs in an estimated 1 in 560 people across the world. Balanced translocations, unless interrupting large and important gene sequences, do not have any other side effects other than infertility due to a higher than average rate of aneuploidy. A special type of translocation is called a Robertsonian translocation.
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Structural rearrangements and viability:
Note that any rearrangement resulting in a significant loss of genetic material is most likely to be lethal. While many rearrangements do not result in a loss of genetic material, the position of a gene on a chromosome can affect its expression. In humans, this can often lead to fetal demise. As with any gene mutation, mutations can be neutral, deleterious, or lethal. Because rearrangements affect much larger regions of DNA, they are much more likely to be deleterious or lethal. Of the above rearrangements, Inversions and Translocations are most likely to cause recurrent miscarriages and carry significant risks of offspring with an unbalanced amount of chromosomes. PGT-SR is indicated for all of the above known structural rearrangements, and varies on the ability, cost, and time to create a probe for your specific mutation.
How are Structural Rearrangements found?
Via a Karyotype, the basic definition being that it is an individual’s collection of chromosomes. The term also refers to a laboratory technique that produces an image of an individual’s chromosomes. The karyotype is used to look for abnormal numbers or structures of chromosomes. A further dive into karyotyping chromosomal abnormalities may be helpful if you like to understand the process.
For some, their mutation is not found until IVF (this was us) and PGT-A screening for aneuploidy found the recurrent abnormalities.
What is this weird sentence they’re using to describe my structural rearrangement?
That’s called Cytogenetic Notation!
45,XX, der(13;14)(q10;q10). That sentence is like a probability or financial mathematics equation, with each symbol and number giving you essential information about your structural rearrangement. (in this instance a Robertsonian translocation)
I’m having a hard time visualizing this. What does this look like?
Example of a Deletion, Duplication, or Inversion
Example of reciprocal and non-reciprocal Translocation
I don’t know if I have a structural rearrangement. How do I know? What are the signs?
It depends. Some experience repeat pregnancy loss (RPL) and their doctor will do a RPL panel. Some, like me, just don’t ever get pregnant, or only experience chemical pregnancies. Some do conceive and find out either during the pregnancy or after birth, some experiencing Termination for Medical Reasons (TFMR). The only way to truly know and confirm is via a Karyotype for you and your partner.
Where can I find more support and research on Structural Rearrangements? (I am not linking the facebook groups. I found them entirely unhelpful and full of triggering content)
Rare Chromo Org (Unique) - This is a source of information and support to families and individuals affected by any rare chromosome disorder and to the professionals who work with them. UK based charity but welcomes members worldwide. Free membership, heavily reliant on donations.
ARC (Antenatal Results and Choices), UK
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Common research links:
https://www.ncbi.nlm.nih.gov/pubmed
https://scholar.google.ca/
http://www.nature.com/ejhg/
https://www.fertstert.org/
https://academic.oup.com/humrep
submitted by Lmahtr to infertility